GIT1

Across TCGA cell cohorts, GIT1 mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GIT1-associated genes across cancer lineages are KLK12, KCNK18, and IFNA14. Each is linked with GIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIT1-to-partner and partner-to-GIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by GIT1-low versus GIT1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIT1→partner) and Y-score (partner→GIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	KCNK18 →	+0.076	+5.977	<.001	.001	3	1
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	1
CNS	H1-8 →	+0.030	+6.357	<.001	<.001	3	1
CNS	OR8K3 →	+0.006	+5.754	.002	.002	3	1
SKIN	TMCO5A →	+0.097	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

KLK12 by GIT1 expression — SOFT_TISSUE

Explore this box plot interactively →