GIPC2

Across TCGA patient cohorts, GIPC2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIPC2-associated genes across cancer lineages are PKC-b-II_pS660, EGFR_pY1068, and eIF4G. Each is linked with GIPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIPC2-to-partner and partner-to-GIPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by GIPC2-low versus GIPC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIPC2→partner) and Y-score (partner→GIPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.342	-2.415	.002	.003	3	2
UCEC	EGFR_pY1068 →	-0.228	-1.906	.023	.016	3	1
UCEC	eIF4G →	+0.349	+2.700	.005	.006	3	1
UCEC	ER-alpha →	-0.759	-2.000	.021	.030	3	1
UCEC	INPP4B →	-0.326	-2.321	.012	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.165	-2.584	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PKC-b-II_pS660 by GIPC2 expression — UCEC

Explore this box plot interactively →