GINS4

Across TCGA pan-cancer cohorts, GINS4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GINS4 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GINS4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GINS4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where GINS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.935	0.553	<.001	26	view →
PDAC	DFS	Quartile	All	0.232	0.646	.002	15	view →
LUAD	DFS	Quartile	All	0.467	0.778	.020	8	view →
HNSC	OS	Median	All	0.805	0.904	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GINS4–LSCC (OS)

Open the LSCC breakdown →