GINS4

Across TCGA pan-cancer cohorts, GINS4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GINS4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GINS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GINS4 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, LUAD, and BLCA are the cancer types where GINS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GINS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.314	<.001	12	view →
LUAD	Male	III,IV	+2.015	<.001	11	view →
BLCA	All	All	+1.353	<.001	11	view →
COAD	All	III,IV	+1.220	<.001	11	view →
KIRP	All	III,IV	+1.178	<.001	11	view →
STAD	Female	All	+1.692	<.001	10	view →
LIHC	Male	All	+0.841	<.001	9	view →
LUSC	Female	II,III,IV	+2.545	<.001	8	view →
UCEC	All	III,IV	+2.510	<.001	8	view →
BRCA	All	II,III,IV	+1.140	<.001	6	view →
ESCA	All	All	+1.165	<.001	5	view →
READ	All	II,III,IV	+0.915	.013	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GINS4–HNSC

Open the HNSC breakdown →