GIMAP1-GIMAP5

Across TCGA pan-cancer cohorts, GIMAP1-GIMAP5 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated GIMAP1-GIMAP5 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GIMAP1-GIMAP5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GIMAP1-GIMAP5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

LUSC, STAD, and KIRC are the cancer types where GIMAP1-GIMAP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.247	0.531	.011	51	view →
STAD	DFS	Tertile	IV	0.068	0.480	<.001	36	view →
KIRC	DFS	Tertile	III,IV	0.792	0.381	.010	36	view →
LAML	DFS	Tertile	All	0.334	0.591	.008	36	view →
KIRP	DFS	Tertile	All	0.202	0.628	<.001	30	view →
DLBC	DFS	Tertile	IV	0.128	1.000	.017	28	view →
MESO	DFS	Tertile	All	0.130	0.482	.011	27	view →
READ	OS	Tertile	III,IV	0.287	0.748	.001	27	view →
ACC	OS	Tertile	All	0.140	0.623	.002	18	view →
LIHC	DFS	Tertile	II,III,IV	0.100	0.463	.048	9	view →
PAAD	OS	Tertile	II,III,IV	0.795	0.560	.036	6	view →
THCA	DFS	Tertile	IV	0.493	0.876	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GIMAP1-GIMAP5–LUSC (OS)

Open the LUSC breakdown →