GIMAP1-GIMAP5

Across TCGA pan-cancer cohorts, GIMAP1-GIMAP5 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GIMAP1-GIMAP5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GIMAP1-GIMAP5 RNA is repressed in tumor relative to normal tissue. In most cancer types GIMAP1-GIMAP5 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and BRCA are the cancer types where GIMAP1-GIMAP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GIMAP1-GIMAP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.020	<.001	6	view →
LUSC	Female	All	−0.045	<.001	5	view →
BRCA	All	All	−0.011	<.001	4	view →
KICH	All	All	−0.016	.008	2	view →
THCA	All	All	−0.006	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GIMAP1-GIMAP5–LUAD

Open the LUAD breakdown →