Across TCGA patient cohorts, GIGYF2 mutation is significantly associated with the RNA expression of many other genes, with 5,377 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIGYF2-associated genes across cancer lineages are SHPK, ATP5PF, and SAAL1. Each is linked with GIGYF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GIGYF2-to-partner and partner-to-GIGYF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIGYF2→partner) and Y-score (partner→GIGYF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SHPK →	+0.382	+2.132	.003	.003	3	4
UCEC	ATP5PF →	+0.289	+1.310	.003	<.001	3	4
UCEC	SAAL1 →	+0.469	+1.545	<.001	<.001	3	4
UCEC	CHAF1A →	+0.558	+1.935	<.001	<.001	3	4
UCEC	UQCRH →	+0.641	+2.147	<.001	<.001	3	4
UCEC	RFC2 →	+0.363	+1.332	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,377 associations by consensus.

Exploration

GIGYF2 survival (RNA) · tumor vs normal (RNA) · all GIGYF2 data types