GIGYF1

Across TCGA pan-cancer cohorts, GIGYF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GIGYF1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GIGYF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GIGYF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where GIGYF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	1.000	0.277	.013	31	view →
UCEC	OS	Tertile	III,IV	0.464	1.000	.040	12	view →
PDAC	OS	Median	II,III,IV	0.291	0.441	.020	4	view →
CCRCC	OS	Median	II,III,IV	1.000	0.449	.032	2	view →
LUAD	OS	Median	II,III,IV	0.861	0.438	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GIGYF1–HNSC (OS)

Open the HNSC breakdown →