GIGYF1

Across TCGA pan-cancer cohorts, GIGYF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GIGYF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GIGYF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GIGYF1 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where GIGYF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GIGYF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.785	<.001	11	view →
KIRP	All	All	+0.577	<.001	11	view →
KIRC	Female	All	+0.495	<.001	11	view →
COAD	Male	II,III,IV	+0.969	<.001	10	view →
LIHC	Female	II,III,IV	+1.580	<.001	9	view →
STAD	All	II,III,IV	+0.783	.005	6	view →
UCEC	All	All	−0.557	<.001	6	view →
CHOL	Female	All	+2.530	<.001	5	view →
READ	Female	All	+0.915	.002	4	view →
BRCA	Female	All	−0.346	<.001	4	view →
LUSC	All	All	+0.336	.018	4	view →
ESCA	All	All	+0.865	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GIGYF1–HNSC

Open the HNSC breakdown →