GIGYF1

Across TCGA patient cohorts, GIGYF1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIGYF1-associated genes across cancer lineages are INPP4B, MEK1, and 4E-BP1. Each is linked with GIGYF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GIGYF1-to-partner and partner-to-GIGYF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GIGYF1-low versus GIGYF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIGYF1→partner) and Y-score (partner→GIGYF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.349	-2.450	.031	.020	3	3
UCEC	MEK1 →	+0.442	+1.999	<.001	<.001	3	3
COAD	4E-BP1 →	+0.268	+2.467	.004	.011	3	3
COAD	ASNS →	+0.359	+3.593	.036	.001	3	3
UCEC	eEF2 →	+0.282	+1.584	.009	.032	3	2
COAD	eIF4E →	+0.224	+2.820	.003	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

INPP4B by GIGYF1 expression — COAD

Explore this box plot interactively →