GIGYF1

Across TCGA cell cohorts, GIGYF1 mutation is significantly associated with the RNA expression of many other genes, with 1,543 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GIGYF1-associated genes across cancer lineages are SGSM3, C12orf57, and OSCP1. Each is linked with GIGYF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIGYF1-to-partner and partner-to-GIGYF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGSM3 grouped by GIGYF1-low versus GIGYF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIGYF1→partner) and Y-score (partner→GIGYF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGSM3 →	+0.663	+2.743	.001	.001	3	2
LARGE_INTESTINE	C12orf57 →	+0.876	+3.252	<.001	.002	3	2
LARGE_INTESTINE	OSCP1 →	+0.587	+2.043	.006	.008	3	2
LARGE_INTESTINE	HELLS →	+0.782	+3.389	.001	.001	3	2
LARGE_INTESTINE	PEX1 →	+0.449	+2.743	.003	.001	3	2
LARGE_INTESTINE	PPP1R3D →	-0.476	-2.571	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,543 associations by consensus.

SGSM3 by GIGYF1 expression — LARGE_INTESTINE

Explore this box plot interactively →