GID4

Across TCGA cell cohorts, GID4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,575 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GID4-associated GO terms across cancer lineages are Regulation of translation at synapse, modulating synaptic transmission, 5-phosphoribose 1-diphosphate biosynthetic process, and 5-phosphoribose 1-diphosphate metabolic process. Each is linked with GID4 in more than 13 cancer types. Because this analysis shows association rather than direction, both GID4-to-partner and partner-to-GID4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation at synapse, modulating synaptic transmission grouped by GID4-low versus GID4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GID4→partner) and Y-score (partner→GID4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of translation at synapse, modulating synaptic transmission →	+0.109	+0.633	<.001	<.001	3	14
OVARY	5-phosphoribose 1-diphosphate biosynthetic process →	+0.113	+0.488	<.001	.001	3	11
OVARY	5-phosphoribose 1-diphosphate metabolic process →	+0.113	+0.488	<.001	.001	3	11
LUNG_NSCLC_LUSC	Nuclear-transcribed mRNA catabolic process →	+0.073	+1.520	.001	.002	3	11
STOMACH	Regulation of translation at synapse →	+0.145	+0.725	<.001	.001	3	10
LUNG_NSCLC_LUSC	mRNA destabilization →	+0.093	+1.382	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,575 associations by consensus.

Regulation of translation at synapse, modulating synaptic transmission by GID4 expression — STOMACH

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