GID4

Across TCGA pan-cancer cohorts, GID4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GID4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GID4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GID4 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where GID4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GID4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.430	.003	8	view →
LUAD	Female	III,IV	−0.775	<.001	7	view →
KIRC	All	All	+0.310	<.001	7	view →
KICH	Female	All	−1.004	<.001	6	view →
BRCA	All	III,IV	−0.685	<.001	6	view →
THCA	Male	All	−0.465	.002	6	view →
CHOL	All	All	+0.761	.001	5	view →
BLCA	Male	IV	−1.605	.013	4	view →
UCEC	All	All	−0.621	<.001	2	view →
LIHC	All	All	+0.289	.006	2	view →
LUSC	All	All	+0.221	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GID4–HNSC

Open the HNSC breakdown →