GHRL

Across TCGA patient cohorts, GHRL mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHRL-associated genes across cancer lineages are PRDX1, EGFR_pY1068, and ACC1. Each is linked with GHRL in more than 1 cancer types. Because this analysis shows association rather than direction, both GHRL-to-partner and partner-to-GHRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by GHRL-low versus GHRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHRL→partner) and Y-score (partner→GHRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.285	+2.584	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.336	-2.906	.001	.001	3	1
UCEC	ACC1 →	+0.428	+2.222	.005	.011	3	1
UCEC	IGFBP2 →	-0.696	-2.222	.011	.011	3	1
UCEC	INPP4B →	-0.288	-2.584	.036	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.167	-2.209	.019	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PRDX1 by GHRL expression — UCEC

Explore this box plot interactively →