GHRL

Across TCGA pan-cancer cohorts, GHRL RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GHRL data layer compared with 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GHRL RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GHRL expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

HNSC, UVM, and LUAD are the cancer types where GHRL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.684	0.525	<.001	130	view →
UVM	DFS	Median	III,IV	0.859	0.446	.001	78	view →
LUAD	OS	Median	All	0.758	0.611	<.001	78	view →
BLCA	OS	Tertile	IV	0.538	0.299	.005	75	view →
UCS	DFS	Quartile	III,IV	0.652	0.163	<.001	70	view →
SKCM	OS	Median	II,III,IV	0.423	0.215	<.001	64	view →
MESO	OS	Median	All	0.493	0.273	<.001	57	view →
CESC	OS	Quartile	All	0.889	0.695	<.001	40	view →
KIRC	DFS	Tertile	All	0.753	0.850	.001	38	view →
UCEC	OS	Quartile	IV	0.891	0.286	.003	34	view →
STAD	DFS	Quartile	II,III,IV	0.373	0.679	.001	31	view →
PAAD	DFS	Tertile	II,III,IV	0.511	0.312	.001	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GHRL–HNSC (DFS)

Open the HNSC breakdown →