GHRH

Across TCGA cell cohorts, GHRH protein abundance is significantly associated with the go_rna of many other GO terms, with 629 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GHRH-associated GO terms across cancer lineages are Negative regulation of pro-B cell differentiation, Mast cell activation, and T cell lineage commitment. Each is linked with GHRH in more than 3 cancer types. Because this analysis shows association rather than direction, both GHRH-to-partner and partner-to-GHRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of pro-B cell differentiation grouped by GHRH-low versus GHRH-high in STOMACH.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GHRH→partner) and Y-score (partner→GHRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of pro-B cell differentiation →	+0.293	+1.728	.002	.001	2	4
BLOOD_Leukemia	Mast cell activation →	+0.136	+1.408	.004	.003	3	3
BLOOD_Lymphoma	T cell lineage commitment →	-0.177	-1.995	<.001	.002	3	3
BONE	Hydrogen peroxide-mediated programmed cell death →	+0.086	+2.423	.006	.002	2	4
BONE	Intrinsic apoptotic signaling pathway in response to hydrogen peroxide →	+0.086	+2.423	.006	.002	2	4
BREAST	Metanephric mesenchymal cell differentiation →	-0.360	-2.380	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 629 associations by consensus.

Negative regulation of pro-B cell differentiation by GHRH expression — STOMACH

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