GHRH

Across TCGA pan-cancer cohorts, GHRH RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated GHRH data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GHRH RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GHRH expression acts as an unfavorable survival marker, although some lineages such as LUSC and SCLC show a favorable association.

KIRC, LIHC, and THCA are the cancer types where GHRH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.494	0.660	.005	68	view →
LIHC	OS	Tertile	III,IV	0.154	0.609	<.001	57	view →
THCA	DFS	Tertile	III,IV	0.184	0.764	<.001	30	view →
DLBC	DFS	Quartile	All	0.414	0.924	.007	22	view →
LUAD	OS	Tertile	IV	0.137	0.606	.013	18	view →
LUSC	OS	Quartile	All	0.833	0.732	.020	17	view →
UVM	OS	Quartile	All	0.467	0.840	<.001	17	view →
READ	DFS	Median	IV	0.347	0.792	.005	12	view →
CESC	DFS	Tertile	IV	0.297	0.600	.035	12	view →
SCLC	DFS	Quartile	All	0.532	0.205	.011	12	view →
GBM	DFS	Median	All	0.362	0.193	.016	9	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GHRH–KIRC (OS)

Open the KIRC breakdown →