GHITM

Across TCGA patient cohorts, GHITM mutation is significantly associated with the immune_cell of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHITM-associated genes across cancer lineages are Monocytes, Platelets, and GMP. Each is linked with GHITM in more than 1 cancer types. Because this analysis shows association rather than direction, both GHITM-to-partner and partner-to-GHITM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by GHITM-low versus GHITM-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHITM→partner) and Y-score (partner→GHITM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	Monocytes →	+0.008	+5.507	.043	.042	3	1
BLCA	Platelets →	+0.018	+3.035	.039	.028	3	1
STAD	GMP →	+0.132	+3.169	<.001	.049	3	1
STAD	MPP →	+0.028	+3.809	<.001	.018	3	1
UCEC	Endothelial cells →	-0.040	-3.313	.010	.010	3	1
UCEC	lymphatic Endothelial cells →	-0.023	-3.660	.020	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Monocytes by GHITM expression — OV

Explore this box plot interactively →