GHITM

Across TCGA pan-cancer cohorts, GHITM RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GHITM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GHITM RNA is repressed in tumor relative to normal tissue. In most cancer types GHITM is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where GHITM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GHITM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.792	<.001	11	view →
THCA	Male	III,IV	−0.794	<.001	10	view →
COAD	Female	All	−0.565	<.001	10	view →
KIRP	Male	All	−0.619	.001	5	view →
READ	All	II,III,IV	−0.692	<.001	4	view →
KICH	All	All	−0.544	<.001	4	view →
LUAD	Male	All	+0.366	.003	3	view →
PRAD	All	All	−0.268	.019	2	view →
BRCA	All	II,III,IV	+0.134	.038	2	view →
LIHC	All	All	+0.187	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GHITM–KIRC

Open the KIRC breakdown →