GHDC

Across TCGA patient cohorts, GHDC mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHDC-associated genes across cancer lineages are mTOR_pS2448, Bax, and C-Raf. Each is linked with GHDC in more than 1 cancer types. Because this analysis shows association rather than direction, both GHDC-to-partner and partner-to-GHDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GHDC-low versus GHDC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHDC→partner) and Y-score (partner→GHDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.189	-3.156	.004	.018	3	2
UCEC	Bax →	+0.291	+2.331	.007	.019	3	2
UCEC	C-Raf →	+0.214	+2.000	<.001	.032	3	2
UCEC	ERK2 →	+0.263	+2.999	.002	.035	3	1
UCEC	GAPDH →	+0.607	+2.999	.012	.035	3	1
UCEC	MEK1 →	+0.415	+3.169	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

mTOR_pS2448 by GHDC expression — UCEC

Explore this box plot interactively →