GHDC

Across TCGA cell cohorts, GHDC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,416 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GHDC-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Sperm motility, and Flagellated sperm motility. Each is linked with GHDC in more than 9 cancer types. Because this analysis shows association rather than direction, both GHDC-to-partner and partner-to-GHDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by GHDC-low versus GHDC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GHDC→partner) and Y-score (partner→GHDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.112	+1.060	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.118	-1.087	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.118	-1.087	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Fatty acid catabolic process →	+0.052	+0.876	.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Fatty acid beta-oxidation →	+0.080	+1.242	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	ER-nucleus signaling pathway →	+0.090	+1.303	<.001	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,416 associations by consensus.

Negative regulation of myoblast fusion by GHDC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →