GH1

Across TCGA pan-cancer cohorts, GH1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GH1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GH1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GH1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, KIRP, and BLCA are the cancer types where GH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.188	0.691	.005	8	view →
KIRP	OS	Median	All	0.118	0.688	.007	6	view →
BLCA	DFS	Median	All	0.133	0.598	.007	6	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
UCEC	DFS	Median	II,III,IV	1.000	0.443	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GH1–COAD (DFS)

Open the COAD breakdown →