GH1

Across TCGA pan-cancer cohorts, GH1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GH1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GH1 RNA is repressed in tumor relative to normal tissue. In most cancer types GH1 is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

BLCA, KIRC, and BRCA are the cancer types where GH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.096	.003	7	view →
KIRC	All	All	+0.063	<.001	7	view →
BRCA	All	III,IV	−0.181	<.001	6	view →
COAD	Female	II,III,IV	−0.144	<.001	6	view →
KICH	All	All	−0.075	.001	5	view →
UCEC	All	All	−0.389	<.001	4	view →
STAD	All	IV	−0.286	<.001	4	view →
READ	All	All	−0.135	.001	2	view →
PRAD	All	All	−0.070	.002	2	view →
LUSC	Female	All	−0.087	.041	1	view →
KIRP	Male	All	−0.028	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GH1–BLCA

Open the BLCA breakdown →