GH1

Across TCGA patient cohorts, GH1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GH1-associated genes across cancer lineages are MPP, Th2 cells, and Eosinophils. Each is linked with GH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GH1-to-partner and partner-to-GH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by GH1-low versus GH1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GH1→partner) and Y-score (partner→GH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MPP →	+0.010	+2.825	.030	.045	3	3
SKCM	Th2 cells →	+0.158	+2.591	.046	.006	3	2
UCEC	Eosinophils →	-0.059	-2.289	.032	.036	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-2.959	.041	.036	3	1
UCEC	pDC →	+0.081	+3.008	<.001	.019	2	2
UCEC	Class-switched memory B-cells →	-0.059	-3.459	.041	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MPP by GH1 expression — LUAD

Explore this box plot interactively →