GH1

Across TCGA cell cohorts, GH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,672 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GH1-associated GO terms across cancer lineages are Negative regulation of cytokine production involved in inflammatory response, Positive regulation of myeloid leukocyte cytokine production involved in immune response, and L-glutamate catabolic process. Each is linked with GH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GH1-to-partner and partner-to-GH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytokine production involved in inflammatory response grouped by GH1-low versus GH1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GH1→partner) and Y-score (partner→GH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of cytokine production involved in inflammatory response →	-0.054	-0.284	<.001	<.001	3	5
BLOOD_Lymphoma	Positive regulation of myeloid leukocyte cytokine production involved in immune response →	+0.057	+0.220	.008	.006	3	4
BLOOD_Lymphoma	L-glutamate catabolic process →	+0.132	+0.303	.004	.004	3	4
BLOOD_Lymphoma	Phospholipase C-activating tachykinin receptor signaling pathway →	-0.568	-0.247	.002	.007	3	4
BLOOD_Leukemia	Podosome assembly →	-0.116	-0.208	<.001	.004	3	4
BONE	Subpallium development →	+0.082	+0.086	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,672 associations by consensus.

Negative regulation of cytokine production involved in inflammatory response by GH1 expression — BLOOD_Leukemia

Explore this box plot interactively →