GH1

Across TCGA cell cohorts, GH1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GH1-associated genes across cancer lineages are PDILT, KCNK18, and KRTAP4-7. Each is linked with GH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GH1-to-partner and partner-to-GH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDILT grouped by GH1-low versus GH1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GH1→partner) and Y-score (partner→GH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDILT →	+0.136	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP4-7 →	+0.270	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	TSPY1 →	+1.271	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PDILT by GH1 expression — LUNG_SCLC

Explore this box plot interactively →