GGTLC3

Across TCGA patient cohorts, GGTLC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,270 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GGTLC3-associated GO terms across cancer lineages are Positive regulation of dendritic cell differentiation, Sequestering of iron ion, and Obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'. Each is linked with GGTLC3 in more than 7 cancer types. Because this analysis shows association rather than direction, both GGTLC3-to-partner and partner-to-GGTLC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of dendritic cell differentiation grouped by GGTLC3-low versus GGTLC3-high in LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GGTLC3→partner) and Y-score (partner→GGTLC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Positive regulation of dendritic cell differentiation →	+0.050	+0.156	<.001	<.001	3	7
LUAD	Sequestering of iron ion →	+0.034	+0.154	<.001	<.001	3	6
KIRP	Obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' →	+0.029	+0.153	<.001	<.001	3	6
BLCA	Glutathione catabolic process →	-0.038	-0.114	<.001	<.001	1	8
KIRP	Regulation of amyloid precursor protein catabolic process →	+0.029	+0.140	<.001	<.001	3	6
KIRP	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.026	+0.131	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,270 associations by consensus.

Positive regulation of dendritic cell differentiation by GGTLC3 expression — LUAD

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