GGTLC3

Across TCGA pan-cancer cohorts, GGTLC3 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated GGTLC3 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher GGTLC3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GGTLC3 expression acts as an unfavorable survival marker, although some lineages such as THCA and KIRP show a favorable association.

THCA, COAD, and LUAD are the cancer types where GGTLC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.895	0.757	<.001	90	view →
COAD	OS	Tertile	III,IV	0.475	0.801	<.001	87	view →
LUAD	DFS	Median	IV	0.381	0.817	.002	30	view →
MESO	OS	Tertile	IV	0.317	0.631	.032	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
HNSC	OS	Tertile	IV	0.156	0.641	.046	18	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
LAML	DFS	Tertile	All	0.266	0.523	.011	18	view →
KIRP	OS	Quartile	II,III,IV	1.000	0.764	.004	15	view →
OV	OS	Tertile	All	0.650	0.701	.041	12	view →
ESCA	OS	Quartile	III,IV	0.762	0.337	.003	12	view →
LIHC	OS	Tertile	All	0.409	0.594	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

GGTLC3–THCA (DFS)

Open the THCA breakdown →