GGT6

Across TCGA patient cohorts, GGT6 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGT6-associated genes across cancer lineages are Annexin_VII, TIGAR, and XBP1. Each is linked with GGT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGT6-to-partner and partner-to-GGT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by GGT6-low versus GGT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT6→partner) and Y-score (partner→GGT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.125	-2.312	.033	.034	3	1
UCEC	TIGAR →	+0.139	+2.248	.031	.006	3	1
UCEC	XBP1 →	-0.216	-2.115	<.001	.017	3	1
UCEC	Cyclin-B1 →	+0.474	+1.700	.047	.044	3	1
UCEC	BRD4 →	+0.287	+3.010	.021	.019	2	1
SKCM	DJ-1 →	+0.219	+3.017	.034	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Annexin_VII by GGT6 expression — UCEC

Explore this box plot interactively →