GGT6

Across TCGA pan-cancer cohorts, GGT6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GGT6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GGT6 RNA is repressed in tumor relative to normal tissue. In most cancer types GGT6 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where GGT6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GGT6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−5.702	<.001	12	view →
KIRP	Male	III,IV	−6.423	<.001	11	view →
HNSC	Female	IV	−2.821	<.001	11	view →
COAD	Female	II,III,IV	−2.280	<.001	11	view →
LUAD	Male	III,IV	−2.053	<.001	10	view →
THCA	Female	II,III,IV	+1.677	<.001	7	view →
LUSC	All	II,III,IV	−1.374	<.001	5	view →
KICH	All	All	−1.197	.009	4	view →
READ	All	All	−2.508	.001	3	view →
LIHC	Male	III,IV	−0.806	<.001	3	view →
CHOL	All	All	+3.433	<.001	2	view →
PRAD	All	All	−1.352	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GGT6–KIRC

Open the KIRC breakdown →