GGT5

Across TCGA pan-cancer cohorts, GGT5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GGT5 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GGT5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GGT5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where GGT5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.418	0.939	.002	30	view →
LUAD	OS	Quartile	All	0.908	0.443	.005	23	view →
CCRCC	DFS	Median	III,IV	0.815	0.387	.002	18	view →
PDAC	OS	Median	IV	0.951	0.381	.006	9	view →
GBM	OS	Quartile	All	0.251	0.512	.042	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GGT5–LSCC (DFS)

Open the LSCC breakdown →