GGH

Across TCGA patient cohorts, GGH mutation is significantly associated with the RNA expression of many other genes, with 645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGH-associated genes across cancer lineages are SAPCD2P2, OR51H1, and LINC02104. Each is linked with GGH in more than 1 cancer types. Because this analysis shows association rather than direction, both GGH-to-partner and partner-to-GGH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAPCD2P2 grouped by GGH-low versus GGH-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGH→partner) and Y-score (partner→GGH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SAPCD2P2 →	+0.228	+4.864	<.001	<.001	3	2
LUSC	OR51H1 →	+0.100	+5.578	.001	.002	3	2
UCEC	LINC02104 →	+0.321	+2.982	<.001	.001	3	1
SKCM	VN1R28P →	+0.079	+3.351	<.001	.008	3	1
SKCM	HIGD2AP1 →	+0.155	+3.123	.004	.007	3	1
SKCM	DEFB130D →	+0.074	+4.147	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

SAPCD2P2 by GGH expression — LUAD

Explore this box plot interactively →