GGACT

Across TCGA pan-cancer cohorts, GGACT mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GGACT data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GGACT mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GGACT expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where GGACT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.383	0.888	<.001	28	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	20	view →
HNSC	DFS	Quartile	III,IV	1.000	0.167	.024	18	view →
UCEC	OS	Tertile	All	1.000	0.897	.029	8	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GGACT–LSCC (DFS)

Open the LSCC breakdown →