GGA3

Across TCGA patient cohorts, GGA3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGA3-associated genes across cancer lineages are ERK2, ATM, and Caspase-8. Each is linked with GGA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGA3-to-partner and partner-to-GGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GGA3-low versus GGA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA3→partner) and Y-score (partner→GGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.168	+3.169	.023	.018	3	2
UCEC	ATM →	-0.477	-2.584	.006	.001	3	2
UCEC	Caspase-8 →	-0.267	-2.584	.005	.001	3	2
UCEC	Ku80 →	+0.200	+1.335	.027	.046	3	1
UCEC	MEK1 →	+0.396	+3.700	.004	.001	3	1
UCEC	Myosin-IIa_pS1943 →	+0.173	+1.335	.028	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ERK2 by GGA3 expression — UCEC

Explore this box plot interactively →