GGA3

Across TCGA pan-cancer cohorts, GGA3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GGA3 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GGA3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GGA3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and MESO show a favorable association.

LIHC, BRCA, and KIRC are the cancer types where GGA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.428	0.657	<.001	76	view →
BRCA	OS	Median	III,IV	0.948	0.856	<.001	56	view →
KIRC	DFS	Tertile	III,IV	0.347	0.601	.003	50	view →
KICH	OS	Quartile	II,III,IV	0.455	1.000	.002	43	view →
MESO	OS	Tertile	All	0.577	0.274	.001	41	view →
HNSC	DFS	Quartile	IV	0.464	0.203	.001	33	view →
LUSC	DFS	Tertile	III,IV	0.304	0.897	.007	28	view →
ACC	DFS	Quartile	II,III,IV	0.382	0.783	.018	20	view →
UCEC	OS	Quartile	IV	0.787	0.300	.007	20	view →
UCS	OS	Tertile	IV	0.675	0.206	.024	18	view →
THYM	OS	Median	II,III,IV	0.955	0.675	.003	18	view →
COAD	DFS	Quartile	II,III,IV	0.641	0.832	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GGA3–LIHC (DFS)

Open the LIHC breakdown →