GGA3

Across TCGA cell cohorts, GGA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,108 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GGA3-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Negative regulation of gene expression, epigenetic, and Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with GGA3 in more than 17 cancer types. Because this analysis shows association rather than direction, both GGA3-to-partner and partner-to-GGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by GGA3-low versus GGA3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA3→partner) and Y-score (partner→GGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.175	+0.923	<.001	<.001	3	18
BONE	Negative regulation of gene expression, epigenetic →	+0.070	+0.804	<.001	<.001	3	18
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.153	+0.839	<.001	<.001	3	17
BONE	Pre-mRNA catabolic process →	+0.192	+0.814	<.001	<.001	3	17
SKIN	Negative regulation of DNA-templated transcription, elongation →	+0.116	+0.921	<.001	<.001	3	17
BONE	Negative regulation of transcription elongation by RNA polymerase II →	+0.142	+1.043	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,108 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by GGA3 expression — BONE

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