GGA3

Across TCGA cell cohorts, GGA3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GGA3-associated genes across cancer lineages are GFRA4, TAAR6, and SLC30A8. Each is linked with GGA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGA3-to-partner and partner-to-GGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by GGA3-low versus GGA3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA3→partner) and Y-score (partner→GGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GFRA4 →	+0.011	+3.584	.009	.004	3	2
SOFT_TISSUE	TAAR6 →	+0.024	+3.977	<.001	.007	3	1
SOFT_TISSUE	SLC30A8 →	+1.119	+3.491	.005	.008	3	1
SOFT_TISSUE	OR6B2 →	+0.038	+3.142	<.001	.008	3	1
SOFT_TISSUE	SPPL2C →	+0.009	+3.584	<.001	.004	3	1
SOFT_TISSUE	ASTL →	+0.051	+3.597	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GFRA4 by GGA3 expression — SOFT_TISSUE

Explore this box plot interactively →