GGA2

Across TCGA patient cohorts, GGA2 mutation is significantly associated with the RNA expression of many other genes, with 1,639 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGA2-associated genes across cancer lineages are TXN2, SENP3-EIF4A1, and TMED7-TICAM2. Each is linked with GGA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GGA2-to-partner and partner-to-GGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXN2 grouped by GGA2-low versus GGA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA2→partner) and Y-score (partner→GGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXN2 →	+0.281	+2.359	.004	<.001	3	3
UCEC	SENP3-EIF4A1 →	+0.087	+2.267	.002	.001	3	2
SKCM	TMED7-TICAM2 →	+0.251	+3.629	.002	.001	3	2
SKCM	MRPL43 →	+0.432	+3.378	.002	.004	3	2
UCEC	PACSIN2 →	+0.465	+2.247	<.001	.001	3	2
UCEC	PHF5A →	+0.417	+2.425	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,639 associations by consensus.

TXN2 by GGA2 expression — UCEC

Explore this box plot interactively →