GGA1

Across TCGA pan-cancer cohorts, GGA1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GGA1 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher GGA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GGA1 expression acts as an unfavorable survival marker.

THYM, BRCA, and BLCA are the cancer types where GGA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BRCA	OS	Median	III,IV	0.211	0.833	<.001	22	view →
BLCA	OS	Median	All	0.141	0.687	.003	21	view →
HNSC	DFS	Median	III,IV	0.208	0.663	.008	21	view →
LUSC	OS	Median	All	0.501	0.776	<.001	20	view →
SKCM	DFS	Median	All	0.015	0.758	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GGA1–THYM (OS)

Open the THYM breakdown →