GGA1

Across TCGA pan-cancer cohorts, GGA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GGA1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GGA1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GGA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where GGA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.917	0.734	.015	15	view →
UCEC	DFS	Tertile	All	1.000	0.743	.003	14	view →
LUAD	DFS	Median	II,III,IV	0.772	0.934	.014	7	view →
LSCC	DFS	Quartile	II,III,IV	0.465	0.941	.006	4	view →
PDAC	DFS	Median	II,III,IV	0.844	0.660	.029	2	view →
CCRCC	DFS	Median	III,IV	0.585	0.841	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GGA1–HNSC (OS)

Open the HNSC breakdown →