GGA1

Across TCGA patient cohorts, GGA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,166 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible GGA1-associated GO terms across cancer lineages are Positive regulation of sphingolipid biosynthetic process, Regulation of sphingolipid biosynthetic process, and Base-excision repair, gap-filling. Each is linked with GGA1 in more than 28 cancer types. Because this analysis shows association rather than direction, both GGA1-to-partner and partner-to-GGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of sphingolipid biosynthetic process grouped by GGA1-low versus GGA1-high in LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA1→partner) and Y-score (partner→GGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Positive regulation of sphingolipid biosynthetic process →	+0.077	+0.655	<.001	<.001	3	29
UVM	Regulation of sphingolipid biosynthetic process →	+0.068	+0.367	<.001	.009	1	27
KIRC	Base-excision repair, gap-filling →	+0.048	+0.480	<.001	<.001	3	25
KIRP	Obsolete regulation of histone methylation →	+0.054	+0.565	<.001	<.001	3	25
SCLC	Obsolete histone modification →	+0.096	+1.910	<.001	<.001	3	24
THYM	COPI-coated vesicle budding →	+0.070	+0.634	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

Positive regulation of sphingolipid biosynthetic process by GGA1 expression — LUAD

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