GGA1

Across TCGA cell cohorts, GGA1 mutation is significantly associated with the mutation status of many other genes, with 5,451 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GGA1-associated genes across cancer lineages are ZFP64, KALRN, and CEP290. Each is linked with GGA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GGA1-to-partner and partner-to-GGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFP64 grouped by GGA1-low versus GGA1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA1→partner) and Y-score (partner→GGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZFP64 →	+5.539	+5.539	<.001	<.001	1	4
UPPER_AERODIGESTIVE_TRACT	KALRN →	+3.217	+4.442	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	CEP290 →	+4.954	+4.392	.008	.008	1	4
BREAST	DYSF →	+3.442	+4.558	.003	.003	1	4
BLOOD_Leukemia	CPS1 →	+3.548	+3.845	.003	.003	1	4
BLOOD_Leukemia	LRRC7 →	+2.870	+3.347	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,451 associations by consensus.

ZFP64 by GGA1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →