GFUS

Across TCGA patient cohorts, GFUS protein abundance is significantly associated with the RNA expression of many other genes, with 12,164 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GFUS-associated genes across cancer lineages are LAS1L, NT5C3B, and DBF4B. Each is linked with GFUS in more than 5 cancer types. Because this analysis shows association rather than direction, both GFUS-to-partner and partner-to-GFUS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GFUS versus LAS1L in LSCC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFUS→partner) and Y-score (partner→GFUS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAS1L →	-0.393	-0.300	<.001	<.001	3	6
LSCC	NT5C3B →	-0.778	-0.380	<.001	<.001	3	6
LSCC	DBF4B →	-0.676	-0.359	<.001	<.001	3	6
LSCC	PSMD11 →	-0.763	-0.276	<.001	<.001	3	5
HNSC	HROB →	-0.961	-0.473	<.001	<.001	3	5
HNSC	ERAL1 →	-0.823	-0.314	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,164 associations by consensus.

GFUS vs LAS1L — LSCC

Explore this scatter interactively →