Across TCGA patient cohorts, GFRAL mutation is significantly associated with the RNA expression of many other genes, with 2,719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFRAL-associated genes across cancer lineages are GNL3, NOL6, and CDT1. Each is linked with GFRAL in more than 2 cancer types. Because this analysis shows association rather than direction, both GFRAL-to-partner and partner-to-GFRAL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRAL→partner) and Y-score (partner→GFRAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNL3 →	+0.472	+1.856	.001	.004	3	3
UCEC	NOL6 →	+0.484	+2.296	<.001	.004	3	3
UCEC	CDT1 →	+0.791	+3.828	<.001	<.001	3	3
UCEC	RFWD3 →	+0.553	+2.392	<.001	<.001	3	3
UCEC	SLC25A33 →	+0.613	+2.178	<.001	.001	3	3
UCEC	ALDH18A1 →	+0.430	+2.354	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,719 associations by consensus.

Exploration

GFRAL survival (RNA) · tumor vs normal (RNA) · all GFRAL data types