Across TCGA pan-cancer cohorts, GFRAL RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of GFRAL’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where GFRAL RNA is repressed in tumor relative to normal tissue. In most cancer types GFRAL is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

BRCA and COAD are the cancer types where GFRAL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GFRAL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.144	<.001	6	view →
COAD	Female	All	−0.009	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: GFRAL RNA expression & survival · all GFRAL data types