Across TCGA cell cohorts, GFRAL RNA expression is significantly associated with the mutation status of many other genes, with 113 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GFRAL-associated genes across cancer lineages are ZNF300, CDK12, and PNPLA8. Each is linked with GFRAL in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRAL-to-partner and partner-to-GFRAL results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRAL→partner) and Y-score (partner→GFRAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF300 →	+5.614	+0.006	.002	<.001	3	2
PANCREAS	CDK12 →	+5.614	+0.006	.002	<.001	3	2
LUNG_SCLC	PNPLA8 →	+4.684	+0.028	<.001	<.001	3	2
LUNG_NSCLC_LUAD	HERC1 →	+2.788	+0.003	.004	<.001	3	2
BLOOD_Leukemia	JAK1 →	+4.984	+0.020	.002	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ELAVL2 →	+3.870	+0.015	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

Exploration

GFRAL survival (RNA) · tumor vs normal (RNA) · all GFRAL data types