Across TCGA cell cohorts, GFRAL mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GFRAL-associated genes across cancer lineages are DEFB124, MCHR2, and APOC3. Each is linked with GFRAL in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRAL-to-partner and partner-to-GFRAL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRAL→partner) and Y-score (partner→GFRAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DEFB124 →	+0.187	+4.108	<.001	.005	3	1
LARGE_INTESTINE	MCHR2 →	+0.033	+4.684	<.001	.002	3	1
LUNG_SCLC	APOC3 →	+1.108	+4.044	<.001	.009	3	1
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	OR10G3 →	+0.047	+4.643	<.001	.004	3	1
LUNG_SCLC	OR7G3 →	+0.047	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

GFRAL survival (RNA) · tumor vs normal (RNA) · all GFRAL data types