GFRA4

Across TCGA patient cohorts, GFRA4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,283 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GFRA4-associated genes across cancer lineages are ARHGAP5, SMARCA1, and ZC3H12B. Each is linked with GFRA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRA4-to-partner and partner-to-GFRA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GFRA4 versus ARHGAP5 in BRCA, with a Pearson correlation of -0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA4→partner) and Y-score (partner→GFRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP5 →	-1.883	-0.515	.004	.002	3	1
BRCA	SMARCA1 →	-1.688	-0.580	.001	<.001	3	1
BRCA	ZC3H12B →	-0.591	-0.540	.006	.001	3	1
BRCA	NFAT5 →	-1.464	-0.719	.001	<.001	3	1
BRCA	RASL12 →	-1.807	-0.730	.009	.001	3	1
BRCA	SFRP1 →	-5.010	-0.679	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,283 associations by consensus.

GFRA4 vs ARHGAP5 — BRCA

Explore this scatter interactively →