GFRA3

Across TCGA pan-cancer cohorts, GFRA3 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of GFRA3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GFRA3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GFRA3 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD and COAD are the cancer types where GFRA3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GFRA3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.857	<.001	8	view →
COAD	All	II,III,IV	−1.986	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

GFRA3–LUAD

Open the LUAD breakdown →