GFRA3

Across TCGA pan-cancer cohorts, GFRA3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GFRA3 data layer compared with 8 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GFRA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GFRA3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UVM show a favorable association.

ACC, LIHC, and MESO are the cancer types where GFRA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.422	0.916	<.001	74	view →
LIHC	DFS	Median	All	0.438	0.636	<.001	57	view →
MESO	OS	Tertile	All	0.463	0.698	.001	49	view →
LGG	OS	Median	All	0.744	0.867	<.001	45	view →
LUAD	OS	Quartile	II,III,IV	0.772	0.454	<.001	45	view →
UVM	OS	Quartile	All	0.766	0.409	<.001	42	view →
KICH	OS	Median	All	0.705	1.000	.006	41	view →
LAML	DFS	Tertile	All	0.742	0.465	.001	38	view →
KIRC	OS	Quartile	II,III,IV	0.667	0.788	.010	28	view →
UCEC	DFS	Median	III,IV	0.864	0.723	.006	24	view →
THYM	DFS	Median	All	0.937	0.799	.007	21	view →
BRCA	DFS	Median	IV	0.323	0.746	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GFRA3–ACC (OS)

Open the ACC breakdown →